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Simulations Plus provides modeling & simulation software and consulting services from discovery through clinical development, with special emphasis on the QSAR-PBPK “marriage” of GastroPlus™ & ADMET Predictor™.

The combination of the industry’s leading PBPK modeling & simulation platform, with the #1-ranked QSAR models, provides an unprecedented ability to screen drugs and chemicals, administered through oral, inhalation, dermal, or IV routes, using virtual animal & human models.

Check out our webinar series to learn how your peers are applying our technology.

•ADMET Predictor provides scientists with an unprecedented capability to data mine compound libraries, quickly design new molecules, generate metabolites, and see how changes in structures affect over 140 ADME-Tox properties.
•Many of these property models feed into GastroPlus, which sets the standard for PBPK/PD modeling for oral (immediate and controlled release formulations), intravenous, inhalation, dermal, and intraoral delivery in human (infants/pediatrics/adults) and animals. Use the program to track plasma or tissue concentrations for parent compounds and any number of metabolites, and easily explore any DDI risks through co-administration of other compounds.
•Two additional products, DDDPlus™ and MembranePlus™, offer mechanistic simulations focused on in vitro dissolution & permeability experiments, respectively, helping you leverage the in vitro-in vivo extrapolation (IVIVE) required for dissolution and absorption modeling.
KIWI™ was created as a cloud-based, validated platform to efficiently and consistently organize, process, and communicate pharmacometric results and the story in front of the pharmacometric analyses.
•And our newest application, PKPlus™, rapidly generates validated NCA/compartmental PK modeling reports for internal research and/or regulatory submissions.

These programs are complemented by our PBPK and pharmacometric modeling and simulation services and clinical pharmacology support, including model-based drug development strategies, PK/PD modeling & simulation, and data assembly. We'll see you in San Diego for AAPS 2017!