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3 Companies with Results for pbpk modeling 1 - 3 of 3

Simulations Plus

42505 10th Street West Lancaster, CA 93534 Tel: +1 661 723-7723

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Resource Center - Simulations Plus

... in Pediatric Populations Using GastroPlus Featured Webinars GastroPlus™ PBPK modeling as a tool to ensure target performance of ... of levofloxacin in humans based on an extrapolated PBPK model Journal Articles Establishment of physiologically based pharmacokinetic model ...

Resource Center - Simulations Plus

... of food effects for Compound A tablet using PBPK model Journal Articles Characterising Drug Release from Immediate-Release ... orbito IMI project Journal Articles Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles Journal Articles Exploring and validating ...

Resource Center - Simulations Plus

... absorption of metformin using a mechanistic oral absorption / PBPK model Posters Exploring Pharmacokinetic SARs Early in Drug Discovery ... Toxicity Endpoints with ANNE Models Posters Mechanistic Absorption/PBPK Modeling to Predict Positive/Negative Food Effects: Approaches and ...

Resource Center - Simulations Plus

... Based Pharmacokinetic Simulations Posters Applying physiologically-based pharmacokinetic (PBPK) modeling & simulation to assist with pharmaceutical research and regulatory ...

Resource Center - Simulations Plus

... v8.5 Webinar – Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization Posters Robust Uncertainty ... Understanding dermal drug disposition using TCAT™ – a novel PBPK model Journal Articles Effect of the pulmonary deposition and ...

Resource Center - Simulations Plus

... absorption of metformin using a mechanistic oral absorption / PBPK model Webinars GastroPlus™ 9.6 Release Webinar: Improvements Supporting ... Toxicity Endpoints with ANNE Models Posters Mechanistic Absorption/PBPK Modeling to Predict Positive/Negative Food Effects: Approaches and ...

PBPK Modeling | DDI Predictions | Mechanistic Absorption

The GastroPlus™ PBPK modeling platform can be applied to support internal research projects through regulatory interactions. See how we combine a user- ...

GastroPlus PBPK Software | Physiologically Based Pharmacokinetic Modeling

GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: PBPKPlus™ What is ... as the #1 PBPK software for Extrapolation (IVIVE) & PBPK modeling by Pfizer! (Cole et al., 2nd Asian Pacific ...

Pharmacokinetics of Biologics | PBPK Modeling of Large Molecules

Use the Biologics Module to easily create PBPK models and simulate the pharmacokinetics of biologics - for both mAbs and ADCs. ... GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: Biologics What is ...

Drug Administration Routes | Mechanistic Absorption Models

... Routes Module in GastroPlus extends your mechanistic absorption/PBPK models by simulating various drug administration routes, including dermal, ... GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: Additional Dosage Routes ...

PBPK Modeling | Pharmacometrics | Clinical Pharmacology | PK/PD Modeling | Clinical Trial Data Analysis

... lots of analysis… Learn how our experts and PBPK modeling technology provides you with solutions at every phase ... we are able to bridge physiologically-based pharmacokinetic (PBPK) modeling with population PK/PD and clinical trial data ...

Resource Center - Simulations Plus

... in DILIsym® v7A? Webinars Mechanistic In Vitro Dissolution PBPK Models to Drive Drug Development Webinars ADMET Predictor™ v8.5 Webinar – Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization Webinars Understanding dermal ...

Nonlinear Pharmacokinetics | PBPK Models | Drug Metabolism | Transport

... allows you to incorporate nonlinear pharmacokinetics into your PBPK models. Learn how your peers are using it. ... GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: Metabolism & Transporter What ...

PBPK Consulting Services | PBPK Modeling Analysis/Simulation

PBPK Modeling and Analysis/Simulation Better understand the PBPK behind your compounds. Simulations Plus offers PBPK consulting services ... ranked Advanced Compartmental Absorption and Transit (ACAT™) and PBPK models, has features and capabilities to support Model Based ...

Resource Center - Simulations Plus

... v8.5 Webinar – Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization Webinars Understanding dermal drug disposition using TCAT™ – a novel PBPK model Featured Webinars MembranePlus™ v2 webinar: Stimulate your kinetic ...

PBPK Modeling Workshops | Population PK Data Analysis Courses

... advancements in model-driven development by attending our PBPK modeling workshops or population PK data analysis courses - register ... science… today. Encouragement from regulatory agencies to incorporate PBPK modeling and population PK/PD data analysis to help ...

PBPK Modeling Workshop | Population PK Analysis | NONMEM Workshop

... science - today! Register for one of our leading PBPK modeling workshops or population PK data analysis courses. ... Workshops Join us for hands-on PBPK modeling, Quantitative Systems Pharmacology ... near you. Space is limited, so register soon! Workshops in Buffalo, ...

PBPK Modeling Workshop | Population PK Analysis | NONMEM Workshop

... science - today! Register for one of our leading PBPK modeling workshops or population PK data analysis courses. ... PBPK Modeling & Population PK Data Analysis Workshops Watch: Workshops 2017 Promo Video PBPK Modeling & Population PK Data Analysis ...

Pharmacodynamics and Pharmacokinetics | PK/PD | PBPK/PD

Extend your PBPK models in GastroPlus by finding relationships between pharmacodynamics and pharmacokinetics with the PDPlus Module using plasma and/or tissue ...

Simulations Plus | Modeling & Simulation Software | Consulting Solutions

... of ADME-Tox property predictions, physiologically-based pharmacokinetic (PBPK) modeling software, and pharmacometric consulting solutions. ... Analyses workshops 2018 Join us for hands-on PBPK modeling, Quantitative Systems Pharmacology (QSP), and population PK/PD ...

Discovery PBPK Simulations | ADMET Predictions | QSAR-PBPK Marriage

GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: ADMET Predictor™ What ... GastroPlus PBPK simulations. You can now apply discovery PBPK modeling approaches to assist with lead selection and optimization ...

Partners and Collaborators - Simulations Plus

... and Pharmacodynamics CRO Partners The demand for QSAR/PBPK modeling support continues to grow, and we encourage CROs ... of the momentum behind the increased use of PBPK modeling has been driven by regulatory agencies around the ...

IVIVC | Mechanistic IVIVC | In Vitro-In Vivo Correlation

GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: IVIVCPlus™ What is ... is that it can be linked to a PBPK model (through the PBPKPlus™ Module ). We are pleased to ...

PBPK Simulations | ADMET Predictions | QSAR-PBPK Marriage

GastroPlus™ PBPK modeling software – from discovery through development… Watch: GastroPlus™ 9.5 Promo Video Choose a Module: ADMET Predictor™ What ... kinetic predictions from chemical structure – quickly create full PBPK models, using the PBPKPlus™ Module , in seconds! Resources Updated! ...

Overview - Simulations Plus

... modeling to assist with drug design efforts, bridge PBPK modeling with pharmacometrics/population PK/PD analyses, provide expanded ... way through regulatory filings, Simulations Plus can help. PBPK Modeling and Analysis/Simulation Better understand the PBPK behind ...

Physiology Model | Deconvolution | Parameter Fitting | Model Building

... use the Optimization Module to build mechanistic absorption/PBPK models with observed data. ... GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: Optimization What is ...

Drug Interactions | DDI Predictions | DDI Risk Assessment

GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: Drug Drug Interaction ... parameters (including reported Kis and full compartmental PK/PBPK models) are defined. Of course, you may predict DDIs ...

GastroPlus User Group - Simulations Plus

... more from the GastroPlus™ User Group. Join the PBPK modeling discussions through the free LinkedIn group. ... you modify liver blood flow values in GastroPlus PBPK models? What are your preferred values for the Percent ...

PBPK - Simulations Plus

... This submodel consists of a physiologically based pharmacokinetic (PBPK) model used to calculate the tissue distribution and elimination ... bind to glutathione (GSH), or be deactivated. Other PBPK modeling platforms, such as GastroPlus™, can be employed to ...

Generic Drugs | Bioequivalence Study | IVIVC FDA | Formulation Development | Dissolution Method

... clock is ticking… Learn how our mechanistic PK/PBPK modeling solutions can help you file generic & 505(b)( ... possible? A small investment in the mechanistic PK/PBPK modeling solutions from Simulations Plus should pay huge dividends – ...

Company Overview - Simulations Plus

... Predictor ™. The combination of the industry’s leading PBPK modeling & simulation platform, with the #1-ranked QSAR models, ... feed into GastroPlus, which sets the standard for PBPK/PD modeling for oral (immediate and controlled release formulations), intravenous, ...

Software Products - Simulations Plus

... key stakeholders to efficiently manage resources. GastroPlus™ Our PBPK modeling & simulation software package which simulates intravenous, oral, oral cavity, ocular, inhalation, dermal/subcutaneous, and intramuscular absorption, PBPK/PD modeling, and drug-drug interactions (DDIs) in virtual human ...

Toxicity modeling | Dermal administration | Oral cavity | Animal testing | Allergic response | Toxicokinetic modeling | Cosmetics | Food Additives

Our ADMET & PBPK modeling can be used to predict efficacy, safety, and exposure of food additives to clear FDA approval. Our tools ... safety. Similar agencies exist in other countries. ADMET modeling and PBPK simulations can be used to predict efficacy, safety, ...

Modeling and Simulations | PBPK Modeling | Webinars

Familiarize yourself with our products and services with these in-depth videos. Watch past videos and/or learn about upcoming webinars. ... Webinars Featured ...

Lead discovery process | Ligand based design | Drug-like/lead-like/fragment-like filters | HTS analysis | QSAR | ADMET Properties | Lead Candidate Selection

... our combination of QSAR models with the GastroPlus™ PBPK modeling platform to predict bioavailability. For example, one can ...

Resource Center - Simulations Plus

... Candidate Optimization and Selection White Papers Application of PBPK Modeling in Generic Drug Evaluation

Pharmacokinetic Studies | PK Modeling | Compartmental PK Models

GastroPlus™ PBPK modeling software – from discovery through regulatory filings… Watch: GastroPlus™ 9.6 Webinar Choose a Module: PKPlus™ What is ...

Fraction absorbed, oral bioavailability | optimal dose

... integrates the industry’s #1-ranked mechanistic absorption/PBPK models with #1-ranked ADME property predictions to predict the following properties in rats or humans: The algorithm uses our Advanced Compartmental Absorption ...

FAQs - Simulations Plus

... mechanistic toxicity assays and information necessary to build PBPK models for predicting liver concentrations. The assays currently used ...

Resource Center - Simulations Plus

... Video Videos Application of Cellular Permeability Simulation and PBPK Models to Capture Significance of Transporter Effects on Dose ...

In Vitro Permeability | Hepatocyte Cellular Concentrations

... measured, and you can better inform your GastroPlus™ PBPK model inputs to predict exposure with confidence. Experimental Design - ...

Events Archive - Simulations Plus

... 5 release webinar: Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization 10 3rd International ...

PBPK Modeling | ADME | Drug Safety | PK/PD Modeling | Allometry

Get to the clinic faster and with more confidence. Learn how our model-driven solutions at Simulations Plus can improve the efficiency of your preclinical ...

DILIsym® - Drug-induced liver injury (DILI) modeling software

... compound absorption, distribution, metabolism, excretion (ADME) in a PBPK sub-model, various intracellular biochemical systems that may be impacted ...

QST and QSP Platform Support

... over 20 scientific papers in the areas of PBPK/PD modeling, in vitro toxicity testing, novel drug delivery systems, ... DILIsym modeling software as well as the NAFLDsym modeling software. Grant ... using mechanistic PBPK/PD to improve decision making during drug discovery ...

The Simulations Plus Customer Portal - Simulations Plus

... ways you can take advantage of our QSAR, PBPK, and/or pharmacometrics modeling & simulation solutions. You may login here to access ...

Physicochemical property prediction | pKa | logP | logD | aqueous solubility

... Predictor module of GastroPlus ™ in order to perform PBPK simulations using predicted properties. Physicochemical property prediction The image below lists the models in ADMET Predictor’s PCB Module. Rat plasma ...

toxicity and exposure modeling | toxicokinetics | PBTK

... relevant properties in order to perform a full PBPK simulation. For example, one can simulate an oral rat acute toxicity test. GastroPlus will predict the fraction absorbed (Fa) using it Advanced Compartmental Absorption and Transit Model (ACAT™). Low Fa values result in reduced chemical ...

Software Installation - Simulations Plus

... incorporate a much larger set of differential equations, PBPK simulations ... a cloud based model using Amazon Web Services (EC2), a scalable, reliable, ...

Careers | Scientists | Pharma Research | BioChem |

About Filter by location: Filter by department: Sr. PBPK Modeler – Competitive pay, full-time employment, travel opportunities ... are currently seeking an experienced Physiologically-based pharmacokinetic (PBPK) modeler for our Simulation Studies team. The position ...

Biochemistry | Chemical Engineering | Biomedical Engineering | Pharma

... in vitro studies, clinical studies as well as PBPK simulations linking non-clinical and clinical data. View ...

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... Predictor™ . The combination of the industry’s leading PBPK modeling & simulation platform, with the #1-ranked QSAR models, ... feed into GastroPlus, which sets the standard for PBPK/PD modeling for oral (immediate and controlled release formulations), intravenous, ...

Certara

210 N Tucker Blvd Ste 350 Saint Louis, MO 63101-1978 Tel: 609-716-7900

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... Portfolio of Simcyp Simulator Licenses Increased Use of PBPK Modeling and Simulation is a Priority in Both the ...

Cyprotex

15 Beech Lane Macclesfield, MA SK10 2DR 269-353-5555

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