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3 Companies with Results for hepatocytes 1 - 3 of 3

BioreclamationIVT

123 Frost St Suite 115 Westbury, NY 11590 Tel: 516-483-1196

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BioreclamationIVT is a worldwide provider of biological and in vitro products to pharmaceutical and biotechnology ...

Simulations Plus

42505 10th Street West Lancaster, CA 93534 Tel: +1 661 723-7723

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Hepatocyte Life Cycle - Simulations Plus

... on DILIsym Choose a Module: What is the Hepatocyte Life Cycle Submodel? This submodel captures the life cycle of the hepatocytes. Explicit tracking of individual hepatocyte pools (necrotic, apoptotic, ...

Caco-2 Cells | In Vitro Permeability | Hepatocytes | Drug Transporters

... vitro permeability (Caco-2, PAMPA, and MDCK cells) & hepatocyte assay studies. Learn how you can use it ... to permeability (e.g., Caco-2 assays) and hepatocyte systems, with several guidelines being published and all ...

DILIsym® - Drug-induced liver injury (DILI) modeling software

... liver injury. It includes key liver cell populations ( , hepatocytes, Kupffer cells), intracellular biochemical systems ( , mitochondrial function), and ... transaminase elevations to predict the underlying level of hepatocyte loss and rate of liver recovery, supporting the ...

In Vitro Permeability | Hepatocyte Cellular Concentrations

... helps you model your in vitro permeability and hepatocyte data to unlock important information from your studies. ... of the drug concentrations from your permeability or hepatocytes studies. Using your measured concentration vs. time data, ...

Resource Center - Simulations Plus

... Drug-Induced Liver Injury. Journal Articles Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and ... Posters Modeling of Active Transport and Metabolism for Hepatocyte Assays with Application of In Vitro to In ...

Clinical Readouts - Simulations Plus

... liver injury such as the fraction of viable hepatocytes, liver levels of adenosine triphosphate (ATP) and glutathione ( ... other various PK outputs. The fraction of viable hepatocytes, is computed over time and can be directly ...

In Vitro Hepatocyte Modeling | Cellular Simulations

... physicochemical & CYP metabolism inputs for your in vitro hepatocyte & permeability simulations. ... metabolism kinetic, parameters required for MembranePlus simulations of hepatocyte or permeability assays. The module uses the same ...

Resource Center - Simulations Plus

... Drug-Induced Liver Injury. Journal Articles Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and ... Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry. Journal Articles Biodegradation ...

Resource Center - Simulations Plus

... and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus Conference Calls 2017 2nd Quarter ... Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry. Journal Articles Biodegradation ...

Resource Center - Simulations Plus

... Posters Modeling of Active Transport and Metabolism for Hepatocyte Assays with Application of In Vitro to In ... and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus Posters Modeling and simulation strategy ...

Resource Center - Simulations Plus

... Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry. Journal Articles Biodegradation ... for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis Journal Articles ...

MITOsym® - Simulations Plus

... dysfunction is assessed by culturing rat or human hepatocytes with varying concentrations of an experimental compound and ... by adding parameterization for primary rat and human hepatocytes. MITOsym v2B included the ability to simulate inhibition ...

Resource Center - Simulations Plus

... and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus Journal Articles Regional intestinal absorption ...

Software Products - Simulations Plus

... the permeability (Caco-2, PAMPA, and MDCK) and hepatocyte assays that accounts for all relevant experimental and ...

FAQs - Simulations Plus

... mediated through the depletion of ATP levels in hepatocytes, with emphasis on oxidative stress induced by reactive ...

Fraction absorbed, oral bioavailability | optimal dose

... clearances from experiments, e.g., liver microsomes or hepatocytes. Estimation of the dose required to reach Ceff ...

Bile Acids - Simulations Plus

... of wielding toxic effects when they accumulate in hepatocytes; inhibition of hepatic efflux transporters such as BSEP, ...

Resource Center - Simulations Plus

... and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus Posters Lead Antimalarial Identification Using ...

NAFLDsym® - Simulations Plus

... the liver cause steatosis and impose lipotoxicity upon hepatocytes that can lead to declining liver function and ...

QST and QSP Platform Support

... liver health and function due to disruptions of hepatocyte biochemistry (e.g., transporter function). Dr. Yang also ...

Reactive Nitrogen/Oxygen Species - Simulations Plus

... of reactive oxygen/nitrogen species (ROS/RNS) in hepatocytes via proposed mechanisms such as the reduction in ...

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... on DILIsym Choose a Module: What is the Hepatocyte Life Cycle Submodel? This submodel captures the life cycle of the hepatocytes. Explicit tracking of individual hepatocyte pools (necrotic, apoptotic, ...

Sekisui XenoTech, LLC

16825 W. 116th St Lenexa, KS 66219 913-438-7450

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